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Clinical course and the role of shiga toxin-producing Escherichia coli infection in the hemolytic-uremic syndrome in pediatric patients, 1997-2000, in Germany and Austria: a prospective study.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2002 Aug 15; Vol. 186 (4), pp. 493-500. Date of Electronic Publication: 2002 Aug 02. - Publication Year :
- 2002
-
Abstract
- Hemolytic-uremic syndrome (HUS) is mainly associated with foodborne infections by Shiga toxin-producing Escherichia coli (STEC). From January 1997 through December 2000, 394 children with HUS were evaluated in a prospective multicenter surveillance study in Germany and Austria (incidences, 0.7/100,000 and 0.4/100,000 children <15 years old, respectively). Blood leukocytosis was associated with increased detection of STEC in stool cultures (P<.01) and a more severe disease course. Risk of death was associated with cerebral involvement (P<.01). Most strikingly, non-O157:H7 STEC were detected in 43% of stool cultures of patients with HUS: O26 was detected in 15%, sorbitol-fermenting O157:H(-) in 10%, O145 in 9%, O103 in 3%, and O111 in 43%. Patients with O157:H7 serotypes required dialysis for a longer time and had bloody diarrhea detected more frequently, compared with patients with non-O157:H7 serotypes (P<.05). This large study in children with HUS underlines the rising importance of non-O157:H7 serotypes, and, despite increased public awareness, the number of patients remained unchanged.
- Subjects :
- Austria epidemiology
Child
Child, Preschool
Culture Media
Escherichia coli classification
Escherichia coli isolation & purification
Escherichia coli Infections microbiology
Escherichia coli O157 classification
Escherichia coli O157 metabolism
Feces microbiology
Female
Germany epidemiology
Hemolytic-Uremic Syndrome microbiology
Humans
Incidence
Infant
Male
Prospective Studies
Sentinel Surveillance
Serotyping
Escherichia coli metabolism
Escherichia coli Infections epidemiology
Escherichia coli Infections physiopathology
Hemolytic-Uremic Syndrome epidemiology
Hemolytic-Uremic Syndrome physiopathology
Shiga Toxins biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 186
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 12195376
- Full Text :
- https://doi.org/10.1086/341940