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Successful allogeneic blood stem cell transplantation for aplastic anemia in a patient with renal insufficiency requiring dialysis.
- Source :
-
Bone marrow transplantation [Bone Marrow Transplant] 2002 Aug; Vol. 30 (3), pp. 195-8. - Publication Year :
- 2002
-
Abstract
- A 27-year-old man with aplastic anemia and renal insufficiency requiring dialysis underwent allogeneic PBSCT. The preparative regimen consisted of melphalan, ATG and TLI. GVHD prophylaxis consisted of cyclosporine and prednisolone. He was dialyzed prior to administration of melphalan and at 24 and 72 h after it. Otherwise, the dialysis schedule was unchanged, at three times a week. Engraftment was rapid. Regimen-related toxicity was minimal. Pharmacokinetic parameters of melphalan were not significantly altered with its plasma half-life 1.5 h. Patients with renal failure can receive allogeneic HSCT, and a combination of melphalan, ATG and TLI may serve as an alternative to CY and ATG.
- Subjects :
- Adult
Anemia, Aplastic complications
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Antineoplastic Combined Chemotherapy Protocols toxicity
Cross Infection prevention & control
Graft Survival
Graft vs Host Disease prevention & control
Humans
Lymphatic Irradiation
Male
Melphalan administration & dosage
Melphalan blood
Melphalan pharmacokinetics
Renal Dialysis
Renal Insufficiency complications
Transplantation Conditioning methods
Transplantation, Homologous
Anemia, Aplastic therapy
Peripheral Blood Stem Cell Transplantation methods
Renal Insufficiency therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0268-3369
- Volume :
- 30
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bone marrow transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 12189539
- Full Text :
- https://doi.org/10.1038/sj.bmt.1703584