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Suppression of inflammation and joint destruction in rheumatoid arthritis may require a concerted action of Th2 cytokines.
- Source :
-
Current opinion in investigational drugs (London, England : 2000) [Curr Opin Investig Drugs] 2002 Jul; Vol. 3 (7), pp. 1011-6. - Publication Year :
- 2002
-
Abstract
- A predominance of T-helper 1 (Th1) activity and a lack of Th2 activity has been documented in the inflamed joints of patients with rheumatoid arthritis (RA). This imbalance is suggested to contribute to activation of, particularly, inflammatory macrophages and B-cells. Th2-mediated immunity, like atopy, is associated with amelioriated inflammation and joint damage in RA patients. Despite the potent anti-inflammatory capacities of two prominent Th2 cytokines in many experimental studies, clinical trials with either human IL-4 or IL-10 in RA patients did not lead to substantial disease suppression. Based on a thorough evaluation of the actions of IL-4 and IL-10 in these studies, it is hypothesized that disease suppression of RA may require the concerted action of suppressive Th2 cytokines or Th2 activity.
- Subjects :
- Animals
Arthritis, Rheumatoid drug therapy
Arthritis, Rheumatoid immunology
Cytokines agonists
Cytokines immunology
Humans
Inflammation immunology
Inflammation prevention & control
Interleukin-10 agonists
Interleukin-10 immunology
Interleukin-10 metabolism
Interleukin-4 agonists
Interleukin-4 immunology
Interleukin-4 metabolism
Th2 Cells drug effects
Th2 Cells immunology
Arthritis, Rheumatoid metabolism
Arthritis, Rheumatoid pathology
Cytokines metabolism
Th2 Cells metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1472-4472
- Volume :
- 3
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Current opinion in investigational drugs (London, England : 2000)
- Publication Type :
- Academic Journal
- Accession number :
- 12186260