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Disinhibition of female sexual behavior by a CRH receptor antagonist in Syrian hamsters.
- Source :
-
American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2002 Sep; Vol. 283 (3), pp. R591-7. - Publication Year :
- 2002
-
Abstract
- Several conditions that inhibit female sexual behavior are thought to be associated with altered corticotropin-releasing hormone (CRH) activity in the brain. The present experiments examined the hypothesis that endogenous CRH receptor signaling mediates the inhibition of estrous behavior by undernutrition and in other instances of sexual dysfunction. Intracerebroventricular (ICV) infusion of CRH or urocortin inhibited estrous behavior in ovariectomized steroid-primed hamsters. Conversely, ICV infusion of the CRH receptor antagonist astressin prevented the suppression of estrous behavior by food deprivation or by ICV administration of neuropeptide Y. Astressin treatment also induced sexual receptivity in nonresponders, animals that do not normally come into heat when treated with hormones, and this effect persisted in subsequent weekly tests in the absence of any further astressin treatment. Activation of the hypothalamo-pituitary-adrenocortical axis was neither necessary nor sufficient to inhibit estrous behavior, indicating that this phenomenon is due to other central actions of CRH receptor agonists. This is the first direct evidence that CRH receptor signaling may be a final common pathway by which undernutrition and other conditions inhibit female sexual behavior.
- Subjects :
- Animal Nutritional Physiological Phenomena
Animals
Corticosterone blood
Cricetinae
Eating drug effects
Estrous Cycle drug effects
Female
Hydrocortisone blood
Hypothalamo-Hypophyseal System drug effects
Hypothalamo-Hypophyseal System physiology
Infertility, Female chemically induced
Infertility, Female physiopathology
Injections, Intraventricular
Mesocricetus
Neuropeptide Y pharmacology
Peptide Fragments pharmacology
Pituitary-Adrenal System drug effects
Pituitary-Adrenal System physiology
Urocortins
Corticotropin-Releasing Hormone pharmacology
Neural Inhibition drug effects
Neuroprotective Agents pharmacology
Receptors, Corticotropin-Releasing Hormone antagonists & inhibitors
Sexual Behavior, Animal drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0363-6119
- Volume :
- 283
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Regulatory, integrative and comparative physiology
- Publication Type :
- Academic Journal
- Accession number :
- 12184992
- Full Text :
- https://doi.org/10.1152/ajpregu.00233.2002