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Shiga toxin 2 induces macrophage-granulocyte colonies from human bone marrow and cord blood stem cells.
- Source :
-
Infection and immunity [Infect Immun] 2002 Sep; Vol. 70 (9), pp. 5316-8. - Publication Year :
- 2002
-
Abstract
- Addition of Shiga toxin 2 to human bone marrow or cord blood cell culture induced macrophage-granulocyte colonies. Although Shiga toxin 2 alone induced colonies mainly composed of macrophages, it induced colonies mainly consisting of granulocytes when combined with physiological doses of interleukin-1beta, granulocyte colony-stimulating factor, or stem cell factor with interleukin-3.
- Subjects :
- Bone Marrow Cells drug effects
Bone Marrow Cells pathology
Colony-Forming Units Assay
Escherichia coli O157 pathogenicity
Fetal Blood cytology
Fetal Blood drug effects
Granulocyte Colony-Stimulating Factor administration & dosage
Granulocytes pathology
HL-60 Cells
Hematopoietic Stem Cells drug effects
Hematopoietic Stem Cells pathology
Hemolytic-Uremic Syndrome etiology
Hemolytic-Uremic Syndrome pathology
Humans
In Vitro Techniques
Interleukin-1 administration & dosage
Interleukin-3 administration & dosage
Jurkat Cells
Macrophages pathology
Shiga Toxin 2 administration & dosage
Stem Cell Factor administration & dosage
Granulocytes drug effects
Hematopoiesis drug effects
Macrophages drug effects
Shiga Toxin 2 toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 0019-9567
- Volume :
- 70
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Infection and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 12183591
- Full Text :
- https://doi.org/10.1128/IAI.70.9.5316-5318.2002