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Spina bifida and folate-related genes: a study of gene-gene interactions.
- Source :
-
Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2002 May-Jun; Vol. 4 (3), pp. 126-30. - Publication Year :
- 2002
-
Abstract
- Purpose: To assess whether interactions of common alleles of two folate genes contribute to spina bifida risk.<br />Methods: Case-control study, comparing 203 children with spina bifida to 583 controls.<br />Results: Homozygosity for the 677C-T allele of 5,10-methylenetetrahydrofolate reductase (MTHFR) alone was associated with an odds ratio for spina bifida of 1.57 (95% confidence interval [CI], 1.02-2.38). For the 844ins68 allele of cystathionine-beta-synthase alone, the odds ratio was 0.83 (95% CI, 0.39-1.64). For the joint genotype, the odds ratio was 3.69 (95% CI, 1.04-13.50).<br />Conclusions: Interactions between common alleles of folate genes might contribute to the risk for spina bifida.
- Subjects :
- Alleles
Case-Control Studies
Child
Child, Preschool
Cystathionine beta-Synthase metabolism
Humans
Infant
Lod Score
Methylenetetrahydrofolate Reductase (NADPH2)
Mutation
Oxidoreductases Acting on CH-NH Group Donors metabolism
Spinal Dysraphism metabolism
Cystathionine beta-Synthase genetics
Folic Acid genetics
Oxidoreductases Acting on CH-NH Group Donors genetics
Spinal Dysraphism genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1098-3600
- Volume :
- 4
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Genetics in medicine : official journal of the American College of Medical Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 12180146
- Full Text :
- https://doi.org/10.1097/00125817-200205000-00005