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Effect of temperature, pH, and corneal birefringence on polarimetric glucose monitoring in the eye.
- Source :
-
Journal of biomedical optics [J Biomed Opt] 2002 Jul; Vol. 7 (3), pp. 321-8. - Publication Year :
- 2002
-
Abstract
- Over the last two decades polarimetry has been investigated as a noninvasive alternative for glucose monitoring in support of diabetic patients. In particular, the anterior chamber of the eye containing the fluid known as the aqueous humor has been confirmed to be the optimal sensing site for polarimetric glucose measurements due to its reasonable pathlength (1 cm), low scatter, and minimal depolarization index. In essence, the eye can be thought of as an optical window into the body. In this paper, we will first introduce the key challenges that must be overcome to make the use of polarized light in the eye a viable method for noninvasive glucose monitoring, summarize our work toward this endeavor, and then report on our latest research, namely, the effect of temperature, pH, and corneal birefringence on our polarimetric glucose monitoring system.
- Subjects :
- Animals
Aqueous Humor metabolism
Biophysical Phenomena
Biophysics
Computer Simulation
Diabetes Mellitus metabolism
Equipment Design
Humans
Hydrogen-Ion Concentration
Models, Biological
Monitoring, Physiologic instrumentation
Optics and Photonics instrumentation
Rabbits
Temperature
Birefringence
Cornea metabolism
Glucose analysis
Glucose metabolism
Monitoring, Physiologic methods
Subjects
Details
- Language :
- English
- ISSN :
- 1083-3668
- Volume :
- 7
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of biomedical optics
- Publication Type :
- Academic Journal
- Accession number :
- 12175281
- Full Text :
- https://doi.org/10.1117/1.1484163