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The incomplete bucindolol evaluation in acute myocardial infarction Trial (BEAT).
- Source :
-
European journal of heart failure [Eur J Heart Fail] 2002 Aug; Vol. 4 (4), pp. 495-9. - Publication Year :
- 2002
-
Abstract
- Unlabelled: The aim of this study was to evaluate the efficacy of adding the beta-blocker bucindolol to standard therapy shortly after a myocardial infarction in a high-risk population with reduced left ventricular function.<br />Methods: The study was planned to include 2000 patients with an enzyme confirmed myocardial infarction and severely reduced left ventricular function determined by echocardiography (corresponding to ejection fraction < or =0.35). The primary endpoint was all cause mortality and the secondary endpoints were time to first event of death, progression of heart failure or reinfarction-and the components. The study was closed early due to discontinuation of development of bucindolol by the manufacturer. Therefore, 170 patients were randomised to receive bucindolol and 173 to receive placebo.<br />Results: There were 27 deaths in the bucindolol group and 30 in the placebo group, hazard ratio of bucindolol 0.88 (95% confidence limits 0.5-1.5; P=0.6). There were 9/4 (bucindolol/placebo, P=0.16) heart failure events and 5/17 (P=0.01) reinfarctions in the bucindolol/placebo groups.<br />Conclusion: Due to early closure it is unknown whether bucindolol changes mortality in high-risk post myocardial infarct patients when added to best medical therapy. The frequency of reinfarction was significantly reduced.
- Subjects :
- Adrenergic beta-Antagonists adverse effects
Adult
Aged
Aged, 80 and over
Drug Therapy, Combination
Female
Heart Failure mortality
Heart Failure physiopathology
Humans
Male
Middle Aged
Myocardial Contraction drug effects
Myocardial Infarction mortality
Myocardial Infarction physiopathology
Propanolamines adverse effects
Survival Rate
Ventricular Dysfunction, Left mortality
Ventricular Dysfunction, Left physiopathology
Ventricular Function, Left drug effects
Adrenergic beta-Antagonists therapeutic use
Heart Failure drug therapy
Myocardial Infarction drug therapy
Propanolamines therapeutic use
Ventricular Dysfunction, Left drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1388-9842
- Volume :
- 4
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- European journal of heart failure
- Publication Type :
- Academic Journal
- Accession number :
- 12167390
- Full Text :
- https://doi.org/10.1016/s1388-9842(02)00032-6