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The hematopoietic system-specific minor histocompatibility antigen HA-1 shows aberrant expression in epithelial cancer cells.
- Source :
-
The Journal of experimental medicine [J Exp Med] 2002 Aug 05; Vol. 196 (3), pp. 359-68. - Publication Year :
- 2002
-
Abstract
- Allogeneic stem cell transplantation (SCT) can induce curative graft-versus-tumor reactions in patients with hematological malignancies and solid tumors. The graft-versus-tumor reaction after human histocompatibility leukocyte antigen (HLA)-identical SCT is mediated by alloimmune donor T cells specific for polymorphic minor histocompatibility antigens (mHags). Among these, the mHag HA-1 was found to be restricted to the hematopoietic system. Here, we report on the HA-1 ribonucleic acid expression by microdissected carcinoma tissues and by single disseminated tumor cells isolated from patients with various epithelial tumors. The HA-1 peptide is molecularly defined, as it forms an immunogenic peptide ligand with HLA-A2 on the cell membrane of carcinoma cell lines. HA-1-specific cytotoxic T cells lyse epithelial tumor cell lines in vitro, whereas normal epithelial cells are not recognized. Thus, HA-1-specific immunotherapy combined with HLA-identical allogeneic SCT may now be feasible for patients with HA-1(+) carcinomas.
- Subjects :
- Hematopoietic Stem Cell Transplantation
Humans
Immunotherapy
Leukocyte Common Antigens genetics
Minor Histocompatibility Antigens immunology
Neoplasms, Glandular and Epithelial therapy
Oligopeptides immunology
RNA, Messenger analysis
T-Lymphocytes, Cytotoxic immunology
Transcription, Genetic
Transplantation, Homologous
Tumor Cells, Cultured
Minor Histocompatibility Antigens genetics
Neoplasms, Glandular and Epithelial metabolism
Oligopeptides genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1007
- Volume :
- 196
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 12163564
- Full Text :
- https://doi.org/10.1084/jem.20011838