Back to Search
Start Over
Cognitive findings in spinocerebellar ataxia type 2: relationship to genetic and clinical variables.
- Source :
-
Journal of the neurological sciences [J Neurol Sci] 2002 Sep 15; Vol. 201 (1-2), pp. 53-7. - Publication Year :
- 2002
-
Abstract
- Several authors have recently reported a broad cognitive impairment in autosomal dominant cerebellar ataxias (ADCAs) patients. However, only a few studies on neuropsychological features in spinocerebellar ataxia type 2 (SCA2) patients are present in the current literature. The aim of this study is to evaluate the cognitive impairment in a wide sample of SCA2 patients and to verify the role of different disease-related factors (age of onset, disease duration, and clinical severity) on intellectual abilities. We administered a battery of neuropsychological tests assessing handedness, attention, short- and long-term verbal and visuo-spatial memory, executive functions, constructive abilities, general intellectual abilities and depression to 18 SCA2 patients belonging to eight families who came to our observation. Evidence of impaired verbal memory, executive functions and attention was found. The cognitive status was partially related to clinical severity rather than to disease duration or age at onset of symptoms. We partially confirmed data on cognitive defects already reported by others but we also found defective attention skills as well as significant lower performances in a nonverbal intelligence task.
- Subjects :
- Adult
Aged
Cognition Disorders diagnosis
Educational Status
Family Health
Female
Humans
Intelligence Tests
Male
Memory
Middle Aged
Neuropsychological Tests
Spinocerebellar Ataxias diagnosis
Cognition Disorders etiology
Cognition Disorders genetics
Spinocerebellar Ataxias complications
Spinocerebellar Ataxias genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0022-510X
- Volume :
- 201
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Journal of the neurological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 12163194
- Full Text :
- https://doi.org/10.1016/s0022-510x(02)00194-6