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Can mitochondrial DNA mutations cause sperm dysfunction?
- Source :
-
Molecular human reproduction [Mol Hum Reprod] 2002 Aug; Vol. 8 (8), pp. 719-21. - Publication Year :
- 2002
-
Abstract
- Very low levels of somatic mitochondrial (mt)DNA deletions have been identified in the semen of infertile men. It has been suggested that these mutations cause infertility through an effect on sperm motility, but there has been no direct evidence to show that mutant mtDNA can affect sperm function. We have carried out semen analysis on a male harbouring the A3243G mtDNA mutation and show that high levels of mutant mtDNA strongly correlate with low sperm motility.
Details
- Language :
- English
- ISSN :
- 1360-9947
- Volume :
- 8
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Molecular human reproduction
- Publication Type :
- Academic Journal
- Accession number :
- 12149402
- Full Text :
- https://doi.org/10.1093/molehr/8.8.719