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Identification of the primary site of metastatic adenocarcinoma in serous effusions. Value of an immunocytochemical panel added to the clinical arsenal.
- Source :
-
Acta cytologica [Acta Cytol] 2002 Jul-Aug; Vol. 46 (4), pp. 651-8. - Publication Year :
- 2002
-
Abstract
- Objective: To use an immunocytochemical panel as ancillary method to identify the origin of adenocarcinomas in serous effusions.<br />Study Design: Serous effusion samples examined cytologically in the Department of Surgical Pathology, A. C. Camargo Hospital, between 1966 and 1990, were investigated. Of 4,297 cases, 2,317 were associated with adenocarcinoma, and 1,099 were positive for adenocarcinoma by cytologic examination. We selected a total of 248 cases of different origins to subject to immunoreactions. A panel composed of CA-125, CA-19.9, HBME-1, lactoferrin and BRST 2 was tested for the efficiency of these antibodies under two conditions: the panel alone and associated with clinical data, such as anatomic localization of the effusion (pleural or ascitic) and patient sex and age.<br />Results: BRST 2 and lactoferrin were both positive in 29.9% of cases of adenocarcinoma of breast origin; CA-125 and HBME-1 were 28.6% and 25.0% positive in cases of adenocarcinoma of the ovaries, respectively. These immunoreactivities were highly specific when compared to the others. The statistical significance of the results was improved by information on the anatomic location of the effusions and patient sex.<br />Conclusion: Our data strongly indicate that BRST 2 and lactoferrin are important components of an immunocytochemical panel used to identify carcinomas of breast origin. Similarly, CA-125 and HBME-1 may be useful in suggesting the ovaries as possible primary sites.
- Subjects :
- Adenocarcinoma pathology
Adenocarcinoma secondary
Apolipoproteins D
Ascitic Fluid immunology
Breast Neoplasms immunology
Breast Neoplasms pathology
Carrier Proteins immunology
Female
Humans
Immunohistochemistry
Lactoferrin immunology
Male
Neoplasm Metastasis pathology
Ovarian Neoplasms immunology
Ovarian Neoplasms pathology
Pleural Effusion, Malignant immunology
Adenocarcinoma diagnosis
Apolipoproteins
Ascitic Fluid pathology
Breast Neoplasms diagnosis
Glycoproteins
Membrane Transport Proteins
Ovarian Neoplasms diagnosis
Pleural Effusion, Malignant pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0001-5547
- Volume :
- 46
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Acta cytologica
- Publication Type :
- Academic Journal
- Accession number :
- 12146025
- Full Text :
- https://doi.org/10.1159/000326970