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Elevated C-reactive protein associates with early-stage carotid atherosclerosis in young subjects with type 1 diabetes.
- Source :
-
Diabetes care [Diabetes Care] 2002 Aug; Vol. 25 (8), pp. 1432-8. - Publication Year :
- 2002
-
Abstract
- Objective: To evaluate whether low-grade inflammation contributes to early-stage advanced carotid atherosclerosis in young subjects with type 1 diabetes.<br />Research Design and Methods: The mean and maximum (max) intima-media thicknesses (IMT) of the carotid artery were assessed using ultrasound B-mode imaging in 55 patients with type 1 diabetes (22 men and 33 women, aged 22.1 +/- 3.6 years (+/- SD), duration of diabetes 14.2 +/- 5.7 years) and 75 age-matched healthy nondiabetic subjects (28 men and 47 women). High-sensitive C-reactive protein (hs-CRP) levels were measured with a latex-enhanced immunonephelometer.<br />Results: The patients with type 1 diabetes had significantly higher hs-CRP levels (median 0.35, range 0.05-1.47 mg/l vs. median 0.14, range 0.05-1.44 mg/l; P = 0.001) as well as significantly higher mean IMT and max IMT than the nondiabetic subjects (mean IMT 0.76 +/- 0.09 vs. 0.72 +/- 0.04 mm, P = 0.003; max IMT 0.84 +/- 0.11 vs. 0.77 +/- 0.06 mm, P < 0.0001). Hs-CRP levels were significantly correlated with the mean and max IMT of patients with type 1 diabetes and with the max IMT of nondiabetic patients. Multivariate regression analyses for both diabetic and nondiabetic subjects as a single group showed that hs-CRP levels are independently correlated with the mean IMT and max IMT levels (P = 0.002 and P = 0.023, respectively) as well as with diastolic blood pressure, sex, and duration of diabetes.<br />Conclusions: Our data indicate that hs-CRP levels are elevated in young patients with type 1 diabetes, possibly corresponding with early-stage advanced carotid atherosclerosis.
- Subjects :
- Adult
Biomarkers
Carotid Artery Diseases epidemiology
Carotid Artery Diseases immunology
Diabetes Mellitus, Type 1 epidemiology
Diabetes Mellitus, Type 1 immunology
Female
Humans
Male
Multivariate Analysis
Risk Factors
Vasculitis epidemiology
Vasculitis immunology
C-Reactive Protein metabolism
Carotid Artery Diseases blood
Diabetes Mellitus, Type 1 blood
Vasculitis blood
Subjects
Details
- Language :
- English
- ISSN :
- 0149-5992
- Volume :
- 25
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Diabetes care
- Publication Type :
- Academic Journal
- Accession number :
- 12145246
- Full Text :
- https://doi.org/10.2337/diacare.25.8.1432