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Constituents of the twigs of Hernandia ovigera that inhibit the transformation of JB6 murine epidermal cells.
- Source :
-
Journal of natural products [J Nat Prod] 2002 Jul; Vol. 65 (7), pp. 1065-8. - Publication Year :
- 2002
-
Abstract
- Activity-guided fractionation of an ethyl acetate extract of the twigs of Hernandia ovigera, using a soft agar assay with JB6 murine epidermal cells, led to the isolation of two new naturally occurring aryltetralin lignans, (7R,8S,7'R,8'R)-(+)-7'-acetyl-5'-methoxypicropodophyllin (1) and (7R,8S,7'R,8'R)-(+)-7'-acetylpicropodophyllin (2), of which 2 was previously identified as a synthetic product, along with eight known compounds, epiyangambin (3), caruilignan C, diasesartemin, (+)-epimagnolin A, N-methylcorydaldine, (-)-5'-methoxyyatein, (+)-syringaresinol dimethyl ether, and (-)-yatein. The structures and stereochemistry of 1 and 2 were determined using spectroscopic methods. Compounds 2 and 3 exhibited significant inhibition of the transformation of murine epidermal JB6 cells, with IC50 values of 0.15 and 0.4 microg/mL, respectively, while the other isolates were regarded as inactive (IC50 >4 microg/mL).
- Subjects :
- Animals
Anticarcinogenic Agents chemistry
Anticarcinogenic Agents pharmacology
Cells, Cultured drug effects
Epidermis drug effects
Indonesia
Inhibitory Concentration 50
Lignans chemistry
Lignans pharmacology
Mice
Molecular Conformation
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Stereoisomerism
Structure-Activity Relationship
Anticarcinogenic Agents isolation & purification
Lignans isolation & purification
Plants, Medicinal chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0163-3864
- Volume :
- 65
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 12141878
- Full Text :
- https://doi.org/10.1021/np020042w