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Role of Helicobacter pylori in gastric carcinogenesis.
- Source :
-
Gastroenterology clinics of North America [Gastroenterol Clin North Am] 2002 Jun; Vol. 31 (2), pp. 517-35, x. - Publication Year :
- 2002
-
Abstract
- Peptic ulcers and gastric malignancies are the two major complication of the course of Helicobacter pylori-associated chronic gastritis. Both gastric adenocarcinomas and MALT lymphomas occur in association with H. pylori infection, and studies support an etiological association. This article discusses the natural history of H. pylori-related gastric carcinogenesis and criteria to identify people susceptible to H. pylori infection-associated gastric cancer. It then reviews the molecular and genetic mechanisms underlying the malignant transformation of the gastric mucosa associated with H. pylori.
- Subjects :
- Adenocarcinoma genetics
Adenocarcinoma microbiology
Animals
Helicobacter Infections genetics
Helicobacter Infections pathology
Humans
Risk Factors
Stomach Neoplasms genetics
Stomach Neoplasms microbiology
Adenocarcinoma etiology
Helicobacter Infections complications
Helicobacter pylori
Stomach Neoplasms etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0889-8553
- Volume :
- 31
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Gastroenterology clinics of North America
- Publication Type :
- Academic Journal
- Accession number :
- 12134616
- Full Text :
- https://doi.org/10.1016/s0889-8553(02)00012-2