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Enteric administration of a live attenuated measles vaccine does not induce protective immunity in a macaque model.
- Source :
-
Vaccine [Vaccine] 2002 Jul 26; Vol. 20 (23-24), pp. 2906-12. - Publication Year :
- 2002
-
Abstract
- To test the option of oral vaccination with a live attenuated measles vaccine (LAV), we have evaluated the potential of an orally administered enteric-coated tablet containing a candidate LAV (strain Leningrad-16, MV-L16). To this end three groups of two cynomolgus macaques each were vaccinated via different routes with 10(3.8) TCID(50) MV-L16 vaccine: intramuscularly (i.m.), intraintestinally (i.i.) upon laparotomy and via enteric-coated tablets. Upon vaccination, MV-L16 could only be isolated from one of the i.m.-vaccinated monkeys and not from any of the other five. Both the i.m.-infected monkeys and one of the i.i.-infected monkeys developed a MV-specific serum antibody response. Also, MV-specific CD8(+) IFN gamma-producing T cells could be demonstrated in all three monkeys that had seroconverted. Upon challenge with wild-type MV 1 year after vaccination, only these three monkeys proved to be protected. These data do not support the viability of the concept of oral vaccination with LAVs.
- Subjects :
- Administration, Oral
Animals
Antibodies, Viral biosynthesis
Humans
Immunoglobulin M blood
Injections
Injections, Intramuscular
Intestine, Small
Macaca fascicularis
Measles immunology
Measles prevention & control
Measles virus immunology
Measles virus isolation & purification
Measles virus pathogenicity
Neutralization Tests
T-Lymphocytes immunology
Tablets, Enteric-Coated
Vaccines, Attenuated administration & dosage
Measles Vaccine administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0264-410X
- Volume :
- 20
- Issue :
- 23-24
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 12126901
- Full Text :
- https://doi.org/10.1016/s0264-410x(02)00231-1