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Lipophilic derivatives of cyclam as new inhibitors of tumor cell growth.

Authors :
Sibert JW
Cory AH
Cory JG
Source :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2002 Jan 21 (2), pp. 154-5.
Publication Year :
2002

Abstract

Two new lipophilic tetraazamacrocycles were prepared and, in contrast to non-lipophilic analogs, found to be potent inhibitors of tumor cell growth in vitro with IC50 values below 10 micromolar.

Details

Language :
English
ISSN :
1359-7345
Issue :
2
Database :
MEDLINE
Journal :
Chemical communications (Cambridge, England)
Publication Type :
Academic Journal
Accession number :
12120348
Full Text :
https://doi.org/10.1039/b107899m