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Studies on new cyclic imides obtained from aminophenazone with analgesic properties. Potent effects of a 3,4-dichloromaleimide derivative.
- Source :
-
Arzneimittel-Forschung [Arzneimittelforschung] 2002; Vol. 52 (6), pp. 455-61. - Publication Year :
- 2002
-
Abstract
- This paper describes the synthesis of new cyclic imides obtained by reaction with aminophenazone (CAS 58-15-1, 4-aminoantipyrine) and different anhydrides with further cyclization with acetic acid under reflux. Their structures were confirmed by spectral data (IR and NMR) and elemental analysis. The analgesic activity of the synthesized compounds was investigated initially with the writhing test in mice and the most promising compound, a 3,4-dichloromaleimide derivative (3), was analyzed using other models of nociception. The results indicated that compound 3 exerts potent analgesic activity in mice, being more active than some reference drugs. The analgesia caused by this compound was not reversed by naloxone in the writhing test. In the hotplate test, compound 3 did not increase the latency period of pain induced by thermal stimuli, confirming that it does not interact with opioid systems.
- Subjects :
- Acetic Acid
Animals
Capsaicin
Formaldehyde
Indicators and Reagents
Male
Mice
Naloxone pharmacology
Narcotic Antagonists pharmacology
Pain drug therapy
Pain prevention & control
Pain Measurement drug effects
Peritonitis chemically induced
Peritonitis prevention & control
Reaction Time drug effects
Structure-Activity Relationship
Aminopyrine analogs & derivatives
Aminopyrine pharmacology
Analgesics, Non-Narcotic chemical synthesis
Analgesics, Non-Narcotic pharmacology
Imides chemical synthesis
Imides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0004-4172
- Volume :
- 52
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Arzneimittel-Forschung
- Publication Type :
- Academic Journal
- Accession number :
- 12109046
- Full Text :
- https://doi.org/10.1055/s-0031-1299914