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[Study of intermittent endocrine therapy in patients presenting with biologic recurrence after radical prostatectomy or radiotherapy].
- Source :
-
Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie [Prog Urol] 2002 Apr; Vol. 12 (2), pp. 240-7. - Publication Year :
- 2002
-
Abstract
- Introduction: Study of the efficacy of intermittent endocrine therapy after failure of local treatment.<br />Material and Methods: 74 patients were treated for biochemical recurrence after radical prostatectomy (n = 30), radiotherapy (n = 28) or radical prostatectomy followed by radiotherapy (n = 16). Treatment (63 patients were treated by antiandrogens alone, 8 by LHRH analogue and 3 by complete androgen suppression) was continued for 6 months after obtaining undetectable PSA levels for patients after radical prostatectomy (and restarted when PSA > 4 ng/ml) or a PSA nadir < 4 ng/ml for the other patients (and restarted for PSA > 10 ng/ml).<br />Results: The duration of periods without treatment represented 50% of the total treatment cycle. With a mean follow-up of 43.8 months, the overall 5-year biochemical progression-free survival rate was 54.6%. On multivariate analysis, factors predictive of biochemical progression were age less than 70 years (p = 0.05), Gleason score greater than or equal to 8 (p = 0.038) and the presence of lymph node metastases (p = 0.05).<br />Conclusion: Intermittent endocrine therapy is a treatment option for patients with recurrence after local treatment. Candidates for intermittent endocrine therapy must be over the age of 70, with localized adenocarcinoma and a Gleason score less than or equal to 7.
- Subjects :
- Age Factors
Aged
Disease Progression
Drug Administration Schedule
Follow-Up Studies
Gonadotropin-Releasing Hormone therapeutic use
Humans
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Prostatectomy methods
Prostatic Neoplasms pathology
Prostatic Neoplasms radiotherapy
Prostatic Neoplasms surgery
Retrospective Studies
Time Factors
Androgen Antagonists therapeutic use
Gonadotropin-Releasing Hormone analogs & derivatives
Neoplasm Recurrence, Local drug therapy
Prostatic Neoplasms drug therapy
Subjects
Details
- Language :
- French
- ISSN :
- 1166-7087
- Volume :
- 12
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie
- Publication Type :
- Academic Journal
- Accession number :
- 12108338