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The Pco proteins are involved in periplasmic copper handling in Escherichia coli.

The Pco proteins are involved in periplasmic copper handling in Escherichia coli.

Authors :
Lee SM
Grass G
Rensing C
Barrett SR
Yates CJ
Stoyanov JV
Brown NL
Source :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2002 Jul 19; Vol. 295 (3), pp. 616-20.
Publication Year :
2002

Abstract

The interactions between the plasmid-borne copper resistance determinant, pco, and the main copper export system in Escherichia coli have been investigated and no direct interaction has been found. The PcoE and PcoC proteins are periplasmic and PcoC binds one Cu ion per protein molecule. PcoA is also periplasmic and can substitute for the chromosomally encoded CueO protein. The pco determinant is proposed to exert its effect through periplasmic handling of excess copper ions and to increase the level of resistance to copper ions above that conferred by copA alone.<br /> ((c) 2002 Elsevier Science (USA).)

Details

Language :
English
ISSN :
0006-291X
Volume :
295
Issue :
3
Database :
MEDLINE
Journal :
Biochemical and biophysical research communications
Publication Type :
Academic Journal
Accession number :
12099683
Full Text :
https://doi.org/10.1016/s0006-291x(02)00726-x