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General synthesis of persistent trityl radicals for EPR imaging of biological systems.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2002 Jul 12; Vol. 67 (14), pp. 4635-9. - Publication Year :
- 2002
-
Abstract
- In this paper we describe the syntheses of the tetraoxygenated triarylmethyl (trityl) radical 14 and the tetrathiatriarylmethyl (trityl) radicals 15 and 16. The syntheses include new and improved preparations of the key intermediate compounds 1 and 2. The new route to compound 2 is noteworthy for its efficiency and its avoidance of the highly toxic compound phosgene as well as the isolation of the air-sensitive 1,2,4,5-benzenetetrathiol.
- Subjects :
- Catalysis
Dioxoles chemistry
Free Radicals chemistry
Heterocyclic Compounds, 3-Ring chemistry
Molecular Structure
Phenols chemistry
Phosgene chemistry
Solutions
Sulfhydryl Compounds chemistry
Temperature
Chemistry, Organic methods
Dioxoles chemical synthesis
Electron Spin Resonance Spectroscopy
Heterocyclic Compounds, 3-Ring chemical synthesis
Trityl Compounds chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3263
- Volume :
- 67
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 12098269
- Full Text :
- https://doi.org/10.1021/jo011068f