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Plaque instability in peripheral vessels.

Authors :
Silva JA
White CJ
Source :
Progress in cardiovascular diseases [Prog Cardiovasc Dis] 2002 May-Jun; Vol. 44 (6), pp. 429-36.
Publication Year :
2002

Abstract

Vulnerable atherosclerotic plaques, those that are prone to rupture, are soft and lipid rich. Other factors that contribute to destabilizing these plaques are inflammation and vasoconstriction. Although less information is available regarding noncoronary vulnerable plaques than the more frequently studied coronary plaques, it appears that the amount of soft lipid "gruel" as well as in situ inflammation plays a crucial role in destabilizing peripheral vascular atherosclerotic plaque, eventually causing its rupture. As in the coronary circulation, it is likely that the majority of acute plaque rupture events are clinically silent. Nevertheless, preventing plaque rupture in the noncoronary circulation is of the utmost importance because this is the presumed mechanism of progression of peripheral vascular atherosclerotic lesions.<br /> (Copyright 2002, Elsevier Science (USA). All rights reserved.)

Details

Language :
English
ISSN :
0033-0620
Volume :
44
Issue :
6
Database :
MEDLINE
Journal :
Progress in cardiovascular diseases
Publication Type :
Academic Journal
Accession number :
12077716
Full Text :
https://doi.org/10.1053/pcad.2002.123472