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Temperature-induced changes in anaerobic capacity of interventricular septum in trained young and middle-aged rats.
- Source :
-
Biogerontology [Biogerontology] 2002; Vol. 3 (3), pp. 155-60. - Publication Year :
- 2002
-
Abstract
- The interventricular site has been proposed as one of the sites for the myocyte cell death with aging and thereby enhancing the possibility of ventricular dysfunction with aging. Variations in lactate dehydrogenase (LDH), a key glycolytic regulatory enzyme along with its isomers were used as indices to evaluate the anaerobic capacity of the interventricular septum (IVS) in 2-month-old (young) and 12-month-old (middle-aged) rats trained to swim at 25 degrees C (cold, C) and 35 degrees C (thermo neutral, N) temperatures. Blood lactate (La) and LDH along with its isoenzymes in the IVS were assessed and compared with untrained and sedentary rats. Increased septal and heart weight was indicative of age-related hypertrophy accompanied by increased septal thickness. Elevated total LDH activity was evident in both the trained groups in the young. The middle-aged animals exhibited lesser variations in LDH and, H and M subunits. The data suggest an efficient adaptability of the IVS of young rats to physical training in contrast to a poor response by the IVS of middle-aged animals.
- Subjects :
- Aging blood
Aging metabolism
Anaerobiosis
Animals
Cardiomegaly blood
Cardiomegaly metabolism
Cardiomegaly physiopathology
Heart Septum metabolism
Heart Ventricles metabolism
Isoenzymes metabolism
L-Lactate Dehydrogenase metabolism
Lactic Acid blood
Male
Organ Size
Rats
Rats, Wistar
Temperature
Aging physiology
Heart physiopathology
Heart Septum physiopathology
Heart Ventricles physiopathology
Swimming physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1389-5729
- Volume :
- 3
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biogerontology
- Publication Type :
- Academic Journal
- Accession number :
- 12075134
- Full Text :
- https://doi.org/10.1023/a:1015634906540