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Infantile and adult testicular germ cell tumors. a different pathogenesis?
- Source :
-
Cancer genetics and cytogenetics [Cancer Genet Cytogenet] 2002 May; Vol. 135 (1), pp. 57-62. - Publication Year :
- 2002
-
Abstract
- Most adult testicular germ cell tumors have a characteristic chromosomal abnormality that is an isochromosome 12p [i(12p)]. Furthermore, these tumors are characterized by a chromosome number in the triploid range and gains and losses of (parts of) specific chromosomes. Cytogenetic investigation of three cases of infantile testicular germ cell tumors, all diagnosed as yolk sac tumors, revealed highly abnormal karyotypes. We found one case to be diploid; the other two cases were in the hypertriploid/hypotetraploid range. Structural abnormalities of chromosomes 1, 3, and 6 were recurrent and no i(12p) was found. Our results, together with data from the literature, suggest that infantile and adult testicular germ cell tumors have a different origin and pathogenetic pathway. Aberrations of chromosomes 1, 3, and 6 may play an important role in the pathogenesis of infantile testicular yolk sac tumors.
- Subjects :
- Adult
Age Factors
Aneuploidy
Child, Preschool
Chromosome Aberrations
Chromosomes, Human ultrastructure
Chromosomes, Human, Pair 1 genetics
Chromosomes, Human, Pair 1 ultrastructure
Chromosomes, Human, Pair 12 ultrastructure
Chromosomes, Human, Pair 3 genetics
Chromosomes, Human, Pair 3 ultrastructure
Chromosomes, Human, Pair 6 genetics
Chromosomes, Human, Pair 6 ultrastructure
Endodermal Sinus Tumor pathology
Germinoma genetics
Germinoma pathology
Humans
In Situ Hybridization, Fluorescence
Infant
Male
Testicular Neoplasms genetics
Testicular Neoplasms pathology
Chromosomes, Human genetics
Chromosomes, Human, Pair 12 genetics
Endodermal Sinus Tumor genetics
Germinoma classification
Testicular Neoplasms classification
Subjects
Details
- Language :
- English
- ISSN :
- 0165-4608
- Volume :
- 135
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cancer genetics and cytogenetics
- Publication Type :
- Academic Journal
- Accession number :
- 12072204
- Full Text :
- https://doi.org/10.1016/s0165-4608(01)00643-4