Back to Search
Start Over
Transcription profile of cells infected with human T-cell leukemia virus type I compared with activated lymphocytes.
- Source :
-
Cancer research [Cancer Res] 2002 Jun 15; Vol. 62 (12), pp. 3562-71. - Publication Year :
- 2002
-
Abstract
- Human T-cell leukemia virus type I (HTLV-I) is the etiologic agent for adult T-cell leukemia and the neurological disorder tropical spastic paraparesis/HTLV-I-associated myelopathy. CD4+ T lymphocytes, the primary hosts for HTLV-I, undergo a series of changes that lead to T-cell activation, immortalization, and transformation. To gain insight into the genetic differences between activated and HTLV-I-infected lymphocytes, we performed Affymetrix GeneChip analysis of activated and HTLV-I-infected cells. Using the Hu6800 GeneChip, we identified approximately 763 genes that had differentially regulated expression in at least three of five HTLV-I cell lines. Classification of these genes into functional groups including cellular receptors, kinases, phosphatases, cytokines, signal proteins, and transcription factors provides insight into genes and pathways that are differentially regulated during HTLV-I transformation.
- Subjects :
- Apoptosis genetics
Cell Cycle Proteins biosynthesis
Cell Cycle Proteins genetics
Cell Transformation, Viral genetics
Cell Transformation, Viral immunology
Cells, Cultured
Cytokines biosynthesis
Cytokines genetics
Gene Expression Profiling
Gene Expression Regulation
Gene Expression Regulation, Viral
Human T-lymphotropic virus 1 metabolism
Humans
Interleukin-2 Receptor alpha Subunit
Jurkat Cells metabolism
Jurkat Cells physiology
RNA, Messenger biosynthesis
RNA, Messenger genetics
Receptors, Interleukin biosynthesis
Receptors, Interleukin genetics
T-Lymphocytes immunology
T-Lymphocytes metabolism
Transcription Factors biosynthesis
Transcription Factors genetics
Transcription, Genetic
Transfection
Human T-lymphotropic virus 1 genetics
Lymphocyte Activation genetics
T-Lymphocytes physiology
T-Lymphocytes virology
Subjects
Details
- Language :
- English
- ISSN :
- 0008-5472
- Volume :
- 62
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Cancer research
- Publication Type :
- Academic Journal
- Accession number :
- 12068005