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Synthesis and antimicrobial activities of N-substituted imides.
- Source :
-
Farmaco (Societa chimica italiana : 1989) [Farmaco] 2002 May; Vol. 57 (5), pp. 421-6. - Publication Year :
- 2002
-
Abstract
- In the field of our research programs concerning novel antimicrobial agents, a series of N-substituted imides was synthesized. These compounds were obtained by cyclization of amido-acids in acetic anhydride/sodium acetate or hexamethyldisilazane/zinc bromide for the hydroxy-aromatic derivatives. The hydroxy-alkyl maleimides were directly prepared by condensation of the corresponding amino-alcohol with maleic anhydride in boiling toluene. Most of N-substituted maleimides showed an interesting antimicrobial activity towards bacteria from the ATCC collection (Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29212, Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853) but the MIC values for P. aeruginosa were always high (128 microg/ml). The imides with alkyl substituents showed higher activities than aromatic analogues with MIC values in the range of 8-32 microg/ml. Comparatively, succinimides were practically inactive.
- Subjects :
- Anti-Bacterial Agents chemical synthesis
Enterococcus faecalis drug effects
Escherichia coli drug effects
In Vitro Techniques
Maleimides chemistry
Microbial Sensitivity Tests
Pseudomonas aeruginosa drug effects
Staphylococcus aureus drug effects
Structure-Activity Relationship
Succinimides chemistry
Anti-Bacterial Agents pharmacology
Maleimides chemical synthesis
Maleimides pharmacology
Succinimides chemical synthesis
Succinimides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-827X
- Volume :
- 57
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Farmaco (Societa chimica italiana : 1989)
- Publication Type :
- Academic Journal
- Accession number :
- 12058815
- Full Text :
- https://doi.org/10.1016/s0014-827x(02)01217-x