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Unusual plasmodium malariae-like parasites in southeast Asia.
- Source :
-
The Journal of parasitology [J Parasitol] 2002 Apr; Vol. 88 (2), pp. 350-7. - Publication Year :
- 2002
-
Abstract
- During malaria surveys in Myanmar, 2 peculiar forms of Plasmodium malariae-like parasites were found. The morphologies of their early trophozoite stages were distinct from that of the typical P. malariae, resembling instead that of Plasmodium vivax, var. minuta, reported by Emin, and Plasmodium tenue, reported by Stephens, both in 1914. Two polymerase chain reaction (PCR)-based diagnoses, which target the same regions in the small subunit ribosomal RNA (SSUrRNA) genes, indicated that these parasites were new variant forms of P. malariae and that they could be separated into 2 genetic types that correlated with the 2 morphological types. Sequence analysis of the SSUrRNA and the circumsporozoite protein genes revealed that they were distinct both from each other and from other known P. malariae isolates and that the P. tenue-like type was closer to a monkey quartan malaria parasite, Plasmodium brasilianum. These results illustrate that the microscopic appearance of human P. malariae parasites may be more varied than previously assumed and suggest the value of molecular tools in the evaluation of malaria morphological variants.
- Subjects :
- Animals
Base Sequence
DNA, Protozoan chemistry
Humans
Malaria blood
Molecular Sequence Data
Myanmar
Nucleic Acid Hybridization
Plasmodium malariae cytology
Plasmodium malariae genetics
Polymerase Chain Reaction
Protozoan Proteins chemistry
Protozoan Proteins genetics
RNA, Ribosomal chemistry
RNA, Ribosomal genetics
Rural Population
Sequence Homology, Nucleic Acid
DNA, Protozoan genetics
Malaria parasitology
Plasmodium malariae classification
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3395
- Volume :
- 88
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of parasitology
- Publication Type :
- Academic Journal
- Accession number :
- 12054010
- Full Text :
- https://doi.org/10.1645/0022-3395(2002)088[0350:UPMLPI]2.0.CO;2