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Creatinine inhibits D-amino acid oxidase.
- Source :
-
Nephron [Nephron] 2002 Jun; Vol. 91 (2), pp. 281-5. - Publication Year :
- 2002
-
Abstract
- Inhibition of D-amino acid oxidase (DAO) activity by various uremic retention products and guanidino compounds was investigated. Creatinine (CTN) was found to inhibit DAO at a similar concentration in the sera of uremic patients. The inhibition was competitive and the K(i) value was 2.7 mM. Moreover, CTN was shown to interact with flavin adenine dinucleotide (FAD), a coenzyme of DAO. The UV spectral change of FAD bound to DAO was observed in the visible region by addition of CTN. These findings suggest that the increase in serum and tissue CTN concentrations might be responsible, in part, for the increase in D-amino acids in the sera of uremic patients.<br /> (Copyright 2002 S. Karger AG, Basel)
- Subjects :
- Alanine blood
Alanine Transaminase metabolism
Creatinine blood
Enzyme Activation drug effects
Flavin-Adenine Dinucleotide metabolism
Humans
In Vitro Techniques
Serine blood
Creatinine pharmacology
D-Amino-Acid Oxidase antagonists & inhibitors
D-Amino-Acid Oxidase metabolism
Uremia enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 1660-8151
- Volume :
- 91
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nephron
- Publication Type :
- Academic Journal
- Accession number :
- 12053066
- Full Text :
- https://doi.org/10.1159/000058405