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Inhibitory effect of olopatadine on antigen-induced eosinophil infiltration and the LFA-1 and Mac-1 expression in eosinophils.
- Source :
-
Japanese journal of pharmacology [Jpn J Pharmacol] 2002 Apr; Vol. 88 (4), pp. 463-6. - Publication Year :
- 2002
-
Abstract
- The inhibitory effect of olopatadine, a new antiallergic drug, on antigen-induced eosinophil infiltration and its mechanisms were examined using the local sensitized rat allergic rhinitis model and isolated IL-5-stimulated rat peritoneal eosinophils. Olopatadine dose-dependently inhibited antigen-induced eosinophil infiltration in the nasal mucosa. Olopatadine dose-dependently repressed the IL-5-induced expressions of CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1) on rat peritoneal eosinophils. However, olopatadine had no effect on IL-5-induced CD49d/CD29 (VLA-4) expression. These results suggest that olopatadine may inhibit antigen-induced eosinophil infiltration through repression of LFA-1 and Mac-1 expression.
- Subjects :
- Administration, Oral
Animals
Cell Movement drug effects
In Vitro Techniques
Integrin alpha4beta1 biosynthesis
Male
Nasal Mucosa pathology
Olopatadine Hydrochloride
Phthalazines pharmacology
Rats
Rhinitis, Allergic, Perennial drug therapy
Rhinitis, Allergic, Perennial pathology
Anti-Allergic Agents pharmacology
Dibenzoxepins pharmacology
Eosinophils drug effects
Histamine H1 Antagonists pharmacology
Lymphocyte Function-Associated Antigen-1 drug effects
Macrophage-1 Antigen biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0021-5198
- Volume :
- 88
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Japanese journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 12046991
- Full Text :
- https://doi.org/10.1254/jjp.88.463