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[Role of HLA phenotype in the formation of chronic hepatitis C virus infection].
- Source :
-
Zhurnal mikrobiologii, epidemiologii i immunobiologii [Zh Mikrobiol Epidemiol Immunobiol] 2002 Mar-Apr (2), pp. 55-7. - Publication Year :
- 2002
-
Abstract
- Clinical, biochemical and immunological parameters depending on HLA-phenotypic features were examined in 107 patients aged 18-78 years with chronic hepatitis C virus (HCV) infection. Clinical and biochemical manifestations (asthenic, pain and cytolytic syndromes, hepatomegalia, hyperbilirubinemia, hypoprothrombin- and proteinemia), observed in hepatitis C, were more pronounced in patients having HLA-A30, B35, B41, Cw2, A1-B35, A9-B8. The carriers of B8 and B35 antigens were found to have inadequate immune response in HCV infection, manifested by progressive chronic process in the liver and the development of cirrhosis in patients with such specificity.
- Subjects :
- Adolescent
Adult
Aged
HLA-A Antigens physiology
HLA-A1 Antigen physiology
HLA-B Antigens physiology
HLA-B35 Antigen physiology
HLA-B8 Antigen physiology
HLA-C Antigens physiology
Hepatitis C, Chronic etiology
Heterozygote
Humans
Middle Aged
Phenotype
Russia
HLA Antigens physiology
Hepatitis C, Chronic immunology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0372-9311
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Zhurnal mikrobiologii, epidemiologii i immunobiologii
- Publication Type :
- Academic Journal
- Accession number :
- 12043154