Back to Search
Start Over
LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival.
- Source :
-
Nature medicine [Nat Med] 2002 Jun; Vol. 8 (6), pp. 613-9. - Publication Year :
- 2002
-
Abstract
- Multiple sclerosis (MS) is a disabling inflammatory demyelinating disease of the central nervous system (CNS) that primarily affects young adults. Available therapies can inhibit the inflammatory component of MS but do not suppress progressive clinical disability. An alternative approach would be to inhibit mechanisms that drive the neuropathology of MS, which often includes the death of oligodendrocytes, the cells responsible for myelinating the CNS. Identification of molecular mechanisms that mediate the stress response of oligodendrocytes to optimize their survival would serve this need. This study shows that the neurotrophic cytokine leukemia inhibitory factor (LIF) directly prevents oligodendrocyte death in animal models of MS. We also demonstrate that this therapeutic effect complements endogenous LIF receptor signaling, which already serves to limit oligodendrocyte loss during immune attack. Our results provide a novel approach for the treatment of MS.
- Subjects :
- Amino Acid Sequence
Animals
Cell Survival
Encephalomyelitis, Autoimmune, Experimental pathology
Growth Inhibitors pharmacology
Leukemia Inhibitory Factor
Leukemia Inhibitory Factor Receptor alpha Subunit
Lymphokines pharmacology
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
Molecular Sequence Data
Oligodendroglia pathology
Peptide Fragments immunology
Receptors, OSM-LIF
Signal Transduction
Growth Inhibitors physiology
Interleukin-6
Lymphokines physiology
Oligodendroglia cytology
Receptors, Cytokine physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1078-8956
- Volume :
- 8
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Nature medicine
- Publication Type :
- Academic Journal
- Accession number :
- 12042813
- Full Text :
- https://doi.org/10.1038/nm0602-613