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Development of immunocompetence: role of micronutrients and microorganisms.
- Source :
-
Nutrition reviews [Nutr Rev] 2002 May; Vol. 60 (5 Pt 2), pp. S68-72. - Publication Year :
- 2002
-
Abstract
- Normal maturation of immune response at birth is both supported and stimulated by the gastrointestinal microenvironment, which provides both nutrients and antigenic microbial exposure to the developing child. Micronutrients, trace elements, and vitamins are present in the local environment and have important regulatory effects on adaptive immune cell function through effects on type of cytokine response. Congenital HIV infection is critically affected by both nutrient imbalance and alteration in gastrointestinal microflora, which may impair growth and development as well as immune response. Studies described here indicate that micronutrient deficiency is common in congenital HIV exposure even where infection has not occurred and that gastrointestinal recolonization may exert a restorative effect on both immune response and growth in children with HIV infection.
- Subjects :
- Bacteriocins immunology
Digestive System immunology
Failure to Thrive prevention & control
HIV Infections congenital
HIV Infections transmission
Humans
Immunity, Cellular
Immunocompetence immunology
Infant
Infant, Newborn
Infectious Disease Transmission, Vertical
Vitamin A Deficiency complications
Digestive System microbiology
HIV Infections immunology
Immunocompetence physiology
Micronutrients physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0029-6643
- Volume :
- 60
- Issue :
- 5 Pt 2
- Database :
- MEDLINE
- Journal :
- Nutrition reviews
- Publication Type :
- Academic Journal
- Accession number :
- 12035862
- Full Text :
- https://doi.org/10.1301/00296640260130777