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Decreased apoptosis and distinct profile of infiltrating cells in the nasal polyps of patients with aspirin hypersensitivity.
- Source :
-
Allergy [Allergy] 2002 Jun; Vol. 57 (6), pp. 493-500. - Publication Year :
- 2002
-
Abstract
- Background: Patients with aspirin-hypersensitive rhinosinusitis/asthma suffer from a severe form of hyperplastic rhinosinusitis with recurrent polyposis. We aimed to assess the presence of apoptotic cells in nasal polyps from aspirin-hypersensitive (AH) and aspirin-tolerant (AT) patients with rhinosinusitis as related to the characteristics of local inflammation.<br />Methods: Nasal polyps obtained from 16 AH patients and 36 AT patients (17 atopic and 19 nonatopic) were stained for eosinophils and metachromatic cells, and in parallel immunocytochemistry was performed to detect CD45RO+, HLA-DR+, CD8+ and CD68+ positive cells. Apoptotic cells were detected by a nick-end labelling technique, TUNEL.<br />Results: The density of apoptotic cells in AH polyps (5.5 + 1.5 cells/mm2) was significantly lower as compared to both atopic (18.7 + 3.8 cells/mm2; P < 0.02;) and nonatopic (21.3 + 5.2 cells/mm2; P < 0.01) AT polyps. The number of eosinophils, mast cells, and CD45RO+ cells were significantly increased in AH compared to AT polyps (P < 0.001), and the density of HLA-DR+ cells in AH patients was higher than in nonatopic (P < 0.02), but not in atopic AT patients. While in AH patients the duration of rhinosinusitis correlated inversely with the number of apoptotic cells (r = - 0.67; P < 0.04), in contrast, in AT atopic patients the duration of rhinosinusitis showed positive correlation with apoptosis (r = 0.89; P < 0.003).<br />Conclusions: We conclude, that decreased apoptosis of inflammatory cells in nasal polyps from ASA-hypersensitive patients, reflects a distinct mechanisms of local inflammation and may be related to persistence and severity of the disease in these patients.
- Subjects :
- Adult
Aged
Antigens, CD physiology
Antigens, Differentiation, Myelomonocytic physiology
Antigens, Surface physiology
CD8-Positive T-Lymphocytes physiology
Drug Hypersensitivity pathology
Eosinophils physiology
HLA-DR Antigens physiology
Humans
Leukocyte Common Antigens physiology
Mast Cells physiology
Middle Aged
Nasal Mucosa cytology
Nasal Mucosa physiopathology
Rhinitis etiology
Rhinitis physiopathology
Sinusitis etiology
Sinusitis physiopathology
Statistics as Topic
Anti-Inflammatory Agents, Non-Steroidal adverse effects
Apoptosis physiology
Aspirin adverse effects
Drug Hypersensitivity etiology
Drug Hypersensitivity physiopathology
Nasal Polyps pathology
Nasal Polyps physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0105-4538
- Volume :
- 57
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Allergy
- Publication Type :
- Academic Journal
- Accession number :
- 12028114
- Full Text :
- https://doi.org/10.1034/j.1398-9995.2002.13508.x