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Localisation of neurotrophin - containing cells in higher vertebrate intestine.
- Source :
-
Anatomy and embryology [Anat Embryol (Berl)] 2002 May; Vol. 205 (2), pp. 135-40. Date of Electronic Publication: 2002 Apr 19. - Publication Year :
- 2002
-
Abstract
- Neurotrophins are structurally related proteins that regulate the development, differentiation and maintenance of many neuronal populations. In higher vertebrates (reptiles, birds and mammals) four neurotrophins have been found: nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin (NT) 3 and NT4/5. In the gut, experimental data and the occurrence of neurotrophin receptors in intestinal neurons and endocrine cells suggest neurotrophin involvement in intestinal physiology. However, very few data are available regarding the cellular localization and distribution of neurotrophins in the gut. In this study we report the presence of NGF, BDNF and NT3 in neurons and endocrine cells of mouse, duck and lizard intestine. In particular, immunoreactivity to NGF was observed: (a) in both endocrine and nerve cells of mouse and duck intestine, (b) in endocrine cells of lizard gut. Immunoreactivity to BDNF was seen: (a) in nerve cells of mouse intestine, (b) in very few endocrine cells of mouse and duck intestine. Immunoreactivity to NT3 was detected: (a) in nerve cells of the mouse intestine, (b) in endocrine and nerve cells of duck and lizard gut. Our results, together with data previously reported, on the distribution of specific neurotrophin receptors, seem to suggest a possible paracrine/autocrine mechanism of neurotrophin action in both the enteric nervous system and endocrine cells.
- Subjects :
- Animals
Ducks
Enteroendocrine Cells cytology
Female
Fluorescent Antibody Technique, Indirect
Immunoenzyme Techniques
Intestines cytology
Lizards
Male
Mice
Neurons cytology
Species Specificity
Enteroendocrine Cells metabolism
Intestinal Mucosa metabolism
Nerve Growth Factors metabolism
Neurons metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0340-2061
- Volume :
- 205
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Anatomy and embryology
- Publication Type :
- Academic Journal
- Accession number :
- 12021915
- Full Text :
- https://doi.org/10.1007/s00429-002-0237-x