Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23.

Authors :: Li J
Yang Y
Peng Y
Austin RJ
van Eyndhoven WG
Nguyen KC
Gabriele T
McCurrach ME
Marks JR
Hoey T
Lowe SW
Powers S
Source :: Nature genetics [Nat Genet] 2002 Jun; Vol. 31 (2), pp. 133-4. Date of Electronic Publication: 2002 May 20.
Publication Year :: 2002
Abstract: We found that PPM1D, encoding a serine/threonine protein phosphatase, lies within an epicenter of the region at 17q23 that is amplified in breast cancer. We show that overexpression of this gene confers two oncogenic phenotypes on cells in culture: attenuation of apoptosis induced by serum starvation and transformation of primary cells in cooperation with RAS.

Subjects :: Apoptosis genetics
Breast Neoplasms etiology
Cell Transformation, Neoplastic genetics
Female
Humans
Oncogenes genetics
Protein Phosphatase 2C
Breast Neoplasms genetics
Chromosomes, Human, Pair 17 genetics
Gene Amplification
Neoplasm Proteins
Phosphoprotein Phosphatases genetics

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