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Pamidronate induces modifications of circulating angiogenetic factors in cancer patients.
- Source :
-
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2002 May; Vol. 8 (5), pp. 1080-4. - Publication Year :
- 2002
-
Abstract
- Purpose: Recently, new experimental data suggested that, besides inhibiting osteoclasts, bisphosphonate may also have an antitumor effect. Antiangionetetic activity is one of the possible mechanisms of anticancer activity attributed to bisphosphonates. The purpose of this study was to evaluate the modifications in angiogenic cytokines levels after pamidronate infusion.<br />Experimental Design: Twenty-five consecutive cancer patients with bone metastases treated monthly with disodium pamidronate infusion were evaluated prospectively for circulating levels of vascular endothelial growth factor (VEGF), gamma-IFN, interleukin (IL)-6, and IL-8 at different time points: just before and after 1, 2, and 7 days after pamidronate infusion.<br />Results: Basal VEGF levels decreased significantly 1, 2, and 7 days after pamidronate infusion. gamma-IFN and IL-6 levels increased 1 day after the infusion but rapidly decreased after 2 days. Moreover, our data showed a statistically significant negative correlation between VEGF and gamma-IFN levels (P < 0.0001) and a positive correlation between VEGF and IL-8 (P = 0.04).<br />Conclusions: This study confirms that pamidronate could have antiangiogenic properties through a significant and lasting decrease of VEGF serum levels.
- Subjects :
- Aged
Angiogenesis Inducing Agents blood
Antineoplastic Agents therapeutic use
Cytokines blood
Diphosphonates therapeutic use
Endothelial Growth Factors blood
Female
Humans
Interferon-gamma blood
Interferon-gamma drug effects
Interleukin-6 blood
Interleukin-8 blood
Linear Models
Lymphokines blood
Lymphokines drug effects
Male
Middle Aged
Neoplasms blood
Pamidronate
Time Factors
Treatment Outcome
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Antineoplastic Agents pharmacology
Cytokines drug effects
Diphosphonates pharmacology
Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1078-0432
- Volume :
- 8
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Clinical cancer research : an official journal of the American Association for Cancer Research
- Publication Type :
- Academic Journal
- Accession number :
- 12006522