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Amsterdam criteria II and endometrial cancer index cases for an accurate selection of HNPCC families.
- Source :
-
Tumori [Tumori] 2002 Jan-Feb; Vol. 88 (1), pp. 18-20. - Publication Year :
- 2002
-
Abstract
- Endometrial carcinoma (EC) is the second most common tumor in hereditary nonpolyposis colorectal cancer (HNPCC), with an incidence rate of 60% by the age of 70 in mutation carriers. The International Collaborative Group on HNPCC revised the Amsterdam criteria and proposed a new, wider definition including extracolonic cancers. The aim of our study was to evaluate the accuracy of a new definition called Amsterdam criteria II. We updated, reclassified and compared the pedigrees of 29 women, already reported as being affected by EC and having a colorectal cancer familial background, according to the two clinical diagnostic criteria for HNPCC (Amsterdam criteria I, ACI, and Amsterdam criteria II, ACII) after two periods of observation (1990-1995 and 1995-2000). According to ACII the frequency of HNPCC in the population under study increased from 0.9% to 3.7% in the period 1990-1995 and from 3.2% to 3.7% in the period 1995-2000. ACII allowed early detection of HNPCC families and thus made it possible to provide them with a suitable surveillance program and genetic testing.
- Subjects :
- Adaptor Proteins, Signal Transducing
Adult
Aged
Carrier Proteins
Colorectal Neoplasms, Hereditary Nonpolyposis genetics
DNA Mutational Analysis
Endometrial Neoplasms genetics
Female
Genetic Testing
Humans
Incidence
Middle Aged
MutL Protein Homolog 1
MutS Homolog 2 Protein
Neoplasm Proteins genetics
Neoplasm Staging
Nuclear Proteins
Patient Selection
Pedigree
Proto-Oncogene Proteins genetics
Colorectal Neoplasms, Hereditary Nonpolyposis diagnosis
DNA-Binding Proteins
Endometrial Neoplasms diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 0300-8916
- Volume :
- 88
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Tumori
- Publication Type :
- Academic Journal
- Accession number :
- 12004844