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Evaluation in nonhuman primates of vaccines against Ebola virus.
- Source :
-
Emerging infectious diseases [Emerg Infect Dis] 2002 May; Vol. 8 (5), pp. 503-7. - Publication Year :
- 2002
-
Abstract
- Ebola virus (EBOV) causes acute hemorrhagic fever that is fatal in up to 90% of cases in both humans and nonhuman primates. No vaccines or treatments are available for human use. We evaluated the effects in nonhuman primates of vaccine strategies that had protected mice or guinea pigs from lethal EBOV infection. The following immunogens were used: RNA replicon particles derived from an attenuated strain of Venezuelan equine encephalitis virus (VEEV) expressing EBOV glycoprotein and nucleoprotein; recombinant Vaccinia virus expressing EBOV glycoprotein; liposomes containing lipid A and inactivated EBOV; and a concentrated, inactivated whole-virion preparation. None of these strategies successfully protected nonhuman primates from robust challenge with EBOV. The disease observed in primates differed from that in rodents, suggesting that rodent models of EBOV may not predict the efficacy of candidate vaccines in primates and that protection of primates may require different mechanisms.
- Subjects :
- Animals
Antibodies, Viral blood
Encephalitis Virus, Venezuelan Equine genetics
Genetic Vectors genetics
Glycoproteins biosynthesis
Glycoproteins genetics
Glycoproteins immunology
Hemorrhagic Fever, Ebola pathology
Hemorrhagic Fever, Ebola virology
Immunization
Macaca fascicularis immunology
Macaca fascicularis virology
Macaca mulatta immunology
Macaca mulatta virology
Nucleoproteins genetics
Nucleoproteins immunology
Replicon genetics
Vaccines, Attenuated administration & dosage
Vaccines, Attenuated immunology
Vaccines, Synthetic administration & dosage
Vaccines, Synthetic immunology
Viral Proteins genetics
Viral Proteins immunology
Viral Vaccines administration & dosage
Ebolavirus immunology
Hemorrhagic Fever, Ebola immunology
Hemorrhagic Fever, Ebola prevention & control
Macaca immunology
Macaca virology
Viral Vaccines immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1080-6040
- Volume :
- 8
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Emerging infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 11996686
- Full Text :
- https://doi.org/10.3201/eid0805.010284