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Identification of potent and selective oxytocin antagonists. Part 2: further investigation of benzofuran derivatives.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2002 May 20; Vol. 12 (10), pp. 1405-11. - Publication Year :
- 2002
-
Abstract
- The paper covers continuing efforts to discover novel, potent and selective oxytocin antagonists. Further benzofuran derivatives with potent oxytocin antagonist activity and good pharmacokinetic parameters are reported. Efforts to improve the in vivo activity of the series are described.
- Subjects :
- Animals
Benzofurans pharmacokinetics
Benzofurans pharmacology
Drug Design
Female
Humans
Kinetics
Models, Molecular
Molecular Conformation
Rats
Receptors, Oxytocin antagonists & inhibitors
Receptors, Oxytocin metabolism
Structure-Activity Relationship
Uterine Contraction drug effects
Benzofurans chemical synthesis
Oxytocin antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 12
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 11992787
- Full Text :
- https://doi.org/10.1016/s0960-894x(02)00160-9