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Statin use, hyperlipidaemia, and the risk of breast cancer.
- Source :
-
British journal of cancer [Br J Cancer] 2002 May 06; Vol. 86 (9), pp. 1436-9. - Publication Year :
- 2002
-
Abstract
- Hydroxymethyl glutaryl coenzyme A inhibitors ("statins") are carcinogenic in rodents and an increased incidence of breast cancer was reported among pravastatin users in one randomised trial. We conducted a case-control study in the General Practice Research Database to evaluate the risk of breast cancer among 50- to 79-year old women treated with statins for hyperlipidaemia. Case and control women were matched by age, general practice, duration of prescription history in the General Practice Research Database, and index date. Adjusting for history of benign breast disease, body mass index, and use of hormone replacement therapy, women currently treated with statins had an estimated relative risk for breast cancer of 1.0 (95% confidence interval 0.6-1.6) compared to women without hyperlipidaemia. Untreated hyperlipidaemia was associated with an increased risk of breast cancer (estimated relative risk 1.6; 95% confidence interval 1.1-2.5). The estimated relative risk among women currently receiving only non-statin lipid-lowering drugs was similar to that of women with untreated hyperlipidaemia (1.8; 95% confidence interval 0.9-3.4). We found no evidence for an increasing trend in breast cancer risk with increasing duration of statin use (median duration 1.8 years, maximum 8.6 years).<br /> (Copyright 2002 Cancer Research UK)
- Subjects :
- Aged
Anticholesteremic Agents therapeutic use
Case-Control Studies
Drug Administration Schedule
Female
Humans
Middle Aged
Pravastatin adverse effects
Pravastatin therapeutic use
Risk Factors
Anticholesteremic Agents adverse effects
Breast Neoplasms epidemiology
Breast Neoplasms etiology
Hyperlipidemias complications
Hyperlipidemias drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0007-0920
- Volume :
- 86
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- British journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 11986777
- Full Text :
- https://doi.org/10.1038/sj.bjc.6600267