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Shape differences in the corpus callosum in first-episode schizophrenia and first-episode psychotic affective disorder.

Authors :
Frumin M
Golland P
Kikinis R
Hirayasu Y
Salisbury DF
Hennen J
Dickey CC
Anderson M
Jolesz FA
Grimson WE
McCarley RW
Shenton ME
Source :
The American journal of psychiatry [Am J Psychiatry] 2002 May; Vol. 159 (5), pp. 866-8.
Publication Year :
2002

Abstract

Objective: The corpus callosum, the largest white matter tract in the brain, is a midline structure associated with the formation of the hippocampus, septum pellucidum, and cingulate cortex, which have been implicated in the pathogenesis of schizophrenia. Corpus callosum shape deformation, therefore, may reflect a midline neurodevelopmental abnormality.<br />Method: Corpus callosum area and shape were analyzed in 14 first-episode psychotic patients with schizophrenia, 19 first-episode psychotic patients with affective disorder, and 18 normal comparison subjects.<br />Results: No statistically significant corpus callosum area differences between groups were found, but there were differences in the structure's shape between the patients with schizophrenia and the comparison subjects. A correlation between width and angle of the corpus callosum was found in patients with affective disorder.<br />Conclusions: Corpus callosum shape abnormalities in first-episode psychotic patients with schizophrenia may reflect a midline neurodevelopmental abnormality.

Details

Language :
English
ISSN :
0002-953X
Volume :
159
Issue :
5
Database :
MEDLINE
Journal :
The American journal of psychiatry
Publication Type :
Academic Journal
Accession number :
11986146
Full Text :
https://doi.org/10.1176/appi.ajp.159.5.866