Back to Search
Start Over
[Calcium-phosphorus metabolism and bone metabolism in postmenopausal patients with the thyroid gland pathology].
- Source :
-
Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2002 Mar (3), pp. 13-6. - Publication Year :
- 2002
-
Abstract
- Bone metabolism markers (bone alkaline phosphatase, ionized calcium, inorganic phosphorus, serum osteocalcin) and urinary excretion of hydroxyproline, Ca2+ and P after overnight fasting and of creatinine were studied in 52 female patients with endemic goiter and hypothyrosis (18 of these with decompensated hypothyrosis, 34 treated with thyroid hormones) and 48 women without thyroid diseases aged 45-60 years with menopause of no longer than 10 years (6.4 +/- 0.43 years). Clinical and x-ray examinations were carried out in all women; hormonal status, basal serum levels of parathyroid hormone and calcitonin were evaluated. A trend to deceleration of bone remodeling was detected in the patients with untreated hypothyrosis in comparison with women without thyroid disease. Signs of increased bone resorption were detected in patients with endemic goiter and hypothyrosis receiving substitute hormone therapy; this gave grounds to refer patients of menopausal age with endemic goiter and hypothyrosis treated with oral thyroxin for a long time to a group at a high risk of osteoporosis and bone fractures and to start preventive osteotropic therapy from the first day of substitute thyroid hormone therapy.
- Subjects :
- Alkaline Phosphatase blood
Calcitonin blood
Calcium blood
Calcium urine
Female
Goiter, Endemic complications
Goiter, Endemic metabolism
Humans
Hydroxyproline urine
Hypothyroidism complications
Middle Aged
Osteocalcin blood
Osteoporosis, Postmenopausal complications
Parathyroid Hormone blood
Thyroid Hormones blood
Bone and Bones metabolism
Calcium metabolism
Hypothyroidism metabolism
Osteoporosis, Postmenopausal metabolism
Phosphorus blood
Subjects
Details
- Language :
- Russian
- ISSN :
- 0869-2084
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Klinicheskaia laboratornaia diagnostika
- Publication Type :
- Academic Journal
- Accession number :
- 11980136