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[Classification, favorable characteristics, prevention and treatment of adverse side-effects associated with Bacillus Calmette-Guerin in the treatment of superficial bladder cancer].
- Source :
-
Annales d'urologie [Ann Urol (Paris)] 2002 Mar; Vol. 36 (2), pp. 120-31. - Publication Year :
- 2002
-
Abstract
- The efficacy of Bacillus Calmette-Guérin (BCG) in the treatment of superficial bladder cancer was first reported by Morales in 1976. Several authors have since demonstrated the efficacy of BCG in the prophylaxis and treatment of high-risk superficial bladder tumors (pT1G3, CIS). Although BCG is now recommended as an adjunctive treatment for superficial bladder tumors, the optimal treatment schedule remains to be defined. Results reported by Lamm suggest that an initial induction cycle of six weekly intravesical BCG instillations is suboptimal unless maintenance therapy (three consecutive weekly instillations) is given 3, 6, 12, 18, 24, 30 and 36 months later. However, the use of maintenance therapy is hindered by troublesome adverse reactions. This article reviews adverse reactions associated with BCG treatment, proposed a classification and discusses their prevention and treatment.
- Subjects :
- Adjuvants, Immunologic administration & dosage
Adjuvants, Immunologic therapeutic use
Administration, Intravesical
BCG Vaccine administration & dosage
BCG Vaccine therapeutic use
Drug Administration Schedule
Humans
Adjuvants, Immunologic adverse effects
BCG Vaccine adverse effects
Urinary Bladder Neoplasms therapy
Subjects
Details
- Language :
- French
- ISSN :
- 0003-4401
- Volume :
- 36
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Annales d'urologie
- Publication Type :
- Academic Journal
- Accession number :
- 11969046
- Full Text :
- https://doi.org/10.1016/s0003-4401(01)00085-7