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Laryngeal effects of stimulation of rostral and ventral pons in the anaesthetized rat.
- Source :
-
Brain research [Brain Res] 2002 May 03; Vol. 934 (2), pp. 97-106. - Publication Year :
- 2002
-
Abstract
- In order to study the importance of two pontine regions modulating laryngeal resistance, electrical current or microinjections of glutamate (10-30 nl, 1-3 nmol) were made into the pontine parabrachial complex and the A5 region in spontaneously breathing anaesthetized rats. Two distinct patterns of laryngeal and respiratory responses were elicited. An increase of subglottal pressure was accompanied with an expiratory facilitatory response consisted of a decrease in both respiratory rate and phrenic nerve activity. A decrease of subglottal pressure was accompanied with an inspiratory facilitatory response consisted of an increase in both respiratory rate and phrenic nerve activity. The modification of laryngeal calibre occurred during both respiratory phases in most cases. The concomitant cardiovascular changes of these responses were also analyzed. Controls using guanethidine to block autonomic responses which might interact with respiratory control were also made. Histological analysis of stimulation sites showed a topographical organization of these responses: laryngeal constriction was evoked from Kölliker-Fuse, medial parabrachial nuclei and A5 region, whilst the laryngeal dilation was evoked from the lateral parabrachial nucleus.
- Subjects :
- Action Potentials drug effects
Animals
Antihypertensive Agents pharmacology
Cardiovascular Physiological Phenomena drug effects
Electric Stimulation
Glutamic Acid metabolism
Glutamic Acid pharmacology
Guanethidine pharmacology
Laryngeal Muscles drug effects
Nerve Net cytology
Nerve Net drug effects
Nerve Net physiology
Neural Pathways drug effects
Neural Pathways physiology
Phrenic Nerve drug effects
Phrenic Nerve physiology
Pons cytology
Pons drug effects
Rats
Rats, Sprague-Dawley
Respiratory Center cytology
Respiratory Center drug effects
Sympathetic Nervous System cytology
Sympathetic Nervous System drug effects
Synaptic Transmission drug effects
Synaptic Transmission physiology
Action Potentials physiology
Laryngeal Muscles innervation
Laryngeal Muscles physiology
Pons physiology
Respiratory Center physiology
Respiratory Physiological Phenomena drug effects
Sympathetic Nervous System physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0006-8993
- Volume :
- 934
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 11955472
- Full Text :
- https://doi.org/10.1016/s0006-8993(02)02364-8