Ab initio folding of multiple-chain proteins.

Authors :: Saunders JA
Gibson KD
Scheraga HA
Source :: Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing [Pac Symp Biocomput] 2002, pp. 601-12.
Publication Year :: 2002
Abstract: Our previous methodology for ab initio prediction of protein structure is extended here to treat multiple-chain proteins. This involved modification of our united-residue (UNRES) force field and our Conformational Space Annealing (CSA) Global Optimization procedure. Good results have been obtained for both a four- and a three-helix protein from the CASP3 exercise.

Subjects :: Dimerization
Disulfides chemistry
Macromolecular Substances
Models, Molecular
Protein Conformation
Proteins chemistry
Thermodynamics
Protein Folding
Protein Subunits
Proteins metabolism

Language :: English
ISSN :: 2335-6928
Database :: MEDLINE
Journal :: Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Publication Type :: Academic Journal
Accession number :: 11928512
Full Text :: https://doi.org/10.1142/9789812799623_0056