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Differential modulation of sodium channel gating and persistent sodium currents by the beta1, beta2, and beta3 subunits.
- Source :
-
Molecular and cellular neurosciences [Mol Cell Neurosci] 2001 Nov; Vol. 18 (5), pp. 570-80. - Publication Year :
- 2001
-
Abstract
- Brain sodium channels are complexes of a pore-forming alpha subunit with auxiliary beta subunits, which are transmembrane proteins that modulate alpha subunit function. The newly cloned beta3 subunit is shown to be expressed broadly in neurons in the central and peripheral nervous systems, but not in glia and most nonneuronal cells. Beta1, beta2, and beta3 subunits are coexpressed in many neuronal cell types, but are differentially expressed in ventromedial nucleus of the thalamus, brain stem nuclei, cerebellar Purkinje cells, and dorsal root ganglion cells. Coexpression of beta1, beta2, and beta3 subunits with Na(v)1.2a alpha subunits in the tsA-201 subclone of HEK293 cells shifts sodium channel activation and inactivation to more positive membrane potentials. However, beta3 is unique in causing increased persistent sodium currents. Because persistent sodium currents are thought to amplify summation of synaptic inputs, expression of this subunit would increase the excitability of specific groups of neurons to all of their inputs.
- Subjects :
- Animals
Cells, Cultured
Central Nervous System cytology
Central Nervous System metabolism
Membrane Potentials physiology
Peripheral Nervous System cytology
Peripheral Nervous System metabolism
Protein Structure, Tertiary physiology
RNA, Messenger metabolism
Rats
Sodium Channels genetics
Cell Membrane metabolism
Nervous System metabolism
Neuroglia metabolism
Neurons metabolism
Sodium Channels metabolism
Synaptic Transmission physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1044-7431
- Volume :
- 18
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Molecular and cellular neurosciences
- Publication Type :
- Academic Journal
- Accession number :
- 11922146
- Full Text :
- https://doi.org/10.1006/mcne.2001.1039