Are the insulin-like growth factors relevant to cancer?

Authors :: Yee D
Source :: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society [Growth Horm IGF Res] 2001 Dec; Vol. 11 (6), pp. 339-45.
Publication Year :: 2001
Abstract: Recognition of molecular pathways relevant to cancer biology have led to advances in prevention and treatment. Numerous laboratory and clinical investigations have implicated the insulin-like growth factors (IGFs) in tumourigenesis. In this review, the evidence for the involvement of IGFs in cancer is discussed. While these data are persuasive, it is clear that additional methods to regulate IGF action in cancer patients are needed to substantiate the role of this growth factor family in cancer biology.<br /> (Copyright 2001 Elsevier Science Ltd.)

Subjects :: Animals
Female
Hormone Antagonists therapeutic use
Humans
Male
Neoplasms physiopathology
Neoplasms therapy
Phenotype
Receptors, Somatomedin physiology
Signal Transduction
Somatomedins antagonists & inhibitors
Neoplasms etiology
Somatomedins physiology

Language :: English
ISSN :: 1096-6374
Volume :: 11
Issue :: 6
Database :: MEDLINE
Journal :: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
Publication Type :: Academic Journal
Accession number :: 11914021
Full Text :: https://doi.org/10.1054/ghir.2001.0256