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Effect of antiallergic drugs on interleukin 5-induced eosinophil infiltration of rat airways.
- Source :
-
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2002 Mar; Vol. 25 (3), pp. 318-22. - Publication Year :
- 2002
-
Abstract
- Interleukin (IL)-5 is thought to play important roles in asthma and to be a potential therapeutic target. An intratracheal injection of murine recombinant IL-5 (3-30 microg/animal) induced a dose-dependent increase in the number of eosinophils in the bronchoalveolar lavage fluid of Brown Norway (BN) rats 24 h after administration. Bovine serum albumin (30pg/animal), used as reference material, did not cause any change. The reaction was not observed in F344 rats. The increase in the number of eosinophils did not accompany bronchial hyperreactivity in BN or F344 rats. Prednisolone (3-10 mg/kg, i.p.) and emedastine (30 mg/kg, p.o.) reduced the increased number of eosinophils induced by the IL-5 challenge. These results suggest that IL-5 is a potent inducer of eosinophils in the airway of BN rats. Prednisolone and emedastine are effective against IL-5-induced eosinophilia.
- Subjects :
- Animals
Benzimidazoles pharmacology
Bronchoalveolar Lavage Fluid cytology
Eosinophils cytology
Eosinophils metabolism
Interleukin-5 pharmacology
Male
Prednisolone pharmacology
Rats
Rats, Inbred F344
Recombinant Proteins antagonists & inhibitors
Recombinant Proteins pharmacology
Anti-Allergic Agents pharmacology
Bronchi pathology
Eosinophils drug effects
Interleukin-5 antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0918-6158
- Volume :
- 25
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biological & pharmaceutical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 11913525
- Full Text :
- https://doi.org/10.1248/bpb.25.318