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Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study.
- Source :
-
Intensive care medicine [Intensive Care Med] 2002 Feb; Vol. 28 (2), pp. 108-21. Date of Electronic Publication: 2001 Dec 04. - Publication Year :
- 2002
-
Abstract
- Objectives: To examine the incidence of infections and to describe them and their outcome in intensive care unit (ICU) patients.<br />Design and Setting: International prospective cohort study in which all patients admitted to the 28 participating units in eight countries between May 1997 and May 1998 were followed until hospital discharge.<br />Patients: A total of 14,364 patients were admitted to the ICUs, 6011 of whom stayed less than 24 h and 8353 more than 24 h.<br />Results: Overall 3034 infectious episodes were recorded at ICU admission (crude incidence: 21.1%). In ICU patients hospitalised longer than 24 h there were 1581 infectious episodes (crude incidence: 18.9%) including 713 (45%) in patients already infected at ICU admission. These rates varied between ICUs. Respiratory, digestive, urinary tracts, and primary bloodstream infections represented about 80% of all sites. Hospital-acquired and ICU-acquired infections were documented more frequently microbiologically than community-acquired infections (71% and 86%, respectively vs. 55%). About 28% of infections were associated with sepsis, 24% with severe sepsis and 30% with septic shock, and 18% were not classified. Crude hospital mortality rates ranged from 16.9% in non-infected patients to 53.6% in patients with hospital-acquired infections at the time of ICU admission and acquiring infection during the ICU stay.<br />Conclusions: The crude incidence of ICU infections remains high, although the rate varies between ICUs and patient subsets, illustrating the added burden of nosocomial infections in the use of ICU resources.
- Subjects :
- Canada epidemiology
Cohort Studies
Community-Acquired Infections classification
Community-Acquired Infections microbiology
Cross Infection classification
Cross Infection microbiology
Europe epidemiology
Humans
Incidence
Israel epidemiology
Length of Stay statistics & numerical data
Male
Middle Aged
Mortality
Community-Acquired Infections epidemiology
Cross Infection epidemiology
Intensive Care Units statistics & numerical data
Sepsis epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 0342-4642
- Volume :
- 28
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Intensive care medicine
- Publication Type :
- Academic Journal
- Accession number :
- 11907653
- Full Text :
- https://doi.org/10.1007/s00134-001-1143-z