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Evaluation of vaccines for atrophic rhinitis--a comparison of three challenge models.
- Source :
-
Vaccine [Vaccine] 2002 Mar 15; Vol. 20 (13-14), pp. 1797-802. - Publication Year :
- 2002
-
Abstract
- We compared three challenge models for the assessment of atrophic rhinitis (AR) vaccines: combined infection with Bordetella bronchiseptica (Bb) and Pasteurella multocida (Pm); application of acetic acid (AA) to the nasal mucosa followed by Pm infection; and Bb infection alone. Two vaccines were tested using standardized criteria, notably nasal lesion scores. The vaccines provided different levels of protection in the Bb and the AA/Pm challenges, but were similar in the combined (Bb/Pm) challenge. It is clear that the AA/Pm model shows the protective value of only the Pm component, whereas the single Bb challenge reflects the protective value merely of the Bb component of a combined vaccine. These results suggest that the best assessment of protection is provided if the two specific challenges are performed separately.
- Subjects :
- Acetic Acid administration & dosage
Administration, Intranasal
Animals
Antibodies, Bacterial blood
Bordetella Infections immunology
Bordetella Infections prevention & control
Bordetella Infections veterinary
Bordetella bronchiseptica immunology
Female
Pasteurella Infections immunology
Pasteurella Infections prevention & control
Pasteurella Infections veterinary
Pasteurella multocida immunology
Pregnancy
Rhinitis, Atrophic immunology
Rhinitis, Atrophic prevention & control
Swine
Swine Diseases immunology
Vaccines, Combined administration & dosage
Bacterial Vaccines administration & dosage
Rhinitis, Atrophic veterinary
Swine Diseases prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 0264-410X
- Volume :
- 20
- Issue :
- 13-14
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 11906767
- Full Text :
- https://doi.org/10.1016/s0264-410x(02)00023-3